Myth #2: Testosterone Replacement Increases Risk of Adverse Cardiovascular Events

FALSE: There were two articles published at the end of 2013 and in the early part of 2014 which purported that men on testosterone supplementation had an increased risk of heart attack, however neither of these studies was particularly well run. They were both observational and retrospective, which severely limits the ability to control variables and is not sufficient to establish causation.
Conversely there exists a multitude of studies that link LOW testosterone to increased cardiovascular disease, and furthermore that testosterone replacement improves cardiovascular and metabolic markers. The NIH conducted one of these studies for the express purpose of investigating the findings of the JAMA study that linked testosterone replacement to increased risk. This follow up study looked at over 24,000 patients and found no increased risk of heart attack in those treated with testosterone.